Charles is The Gregory Foltz, MD Endowed Director of the Ben & Catherine Ivy Center for Advanced Brain Tumor Treatment at Swedish Neuroscience Specialists. Charles is a board-certified neurosurgeon who specializes in brain tumors with a combination of hands-on neurosurgery and high-level laboratory research. Prior to joining Swedish, he served as Associate Clinical Professor at UCSF Department of Neurological Surgery, Staff Neurosurgeon at California Pacific Medical Center and Scientist at California Pacific Medical Center Research Institute.
Santosh holds a doctorate in molecular biology and is an expert in brain cancer and practices what he terms “human science” – translational research that blends laboratory science and clinical practice to bring innovative, personalized treatment directly to patients.
His research involves immunotherapy, molecular genetics, innovative drug development for cancer stem cells and development of novel biomarker-based clinical trials for cancers. Before joining Providence Saint John's, he was professor of neurosciences at the University of California, San Diego, School of Medicine, and Director of Neuro-oncology at Moores UC San Diego Cancer Center.
A physician and scientist, Santosh develops targeted drug therapies that will advance the treatment of brain tumors to a new level. An estimated 18,000 Americans are diagnosed with primary brain and spine tumors each year. He cares for these patients as well as a large and growing number of patients with metastatic brain tumors originating from cancers in the breast, lung, skin and other sources. Santosh also cares for and studies autoimmune neurological disorders including cancer-related encephalitis as well as direct treatment-related toxicities from radiation and chemotherapy such as chemobrain and peripheral neuropathy.
Dr. Leary is an attending physician in the Cancer and Blood Disorders Center at Seattle Children’s Hospital and Associate Professor of Pediatrics at the University of Washington School of Medicine. Her clinical and research focus is in the area of pediatric brain tumors. Locally, she serves on the Tumor Tissue Subcommittee and the Research Review Committee; Nationally, she is leading several clinical trials to study new medications for children with brain tumors at Seattle Children's Hospital, through the Children's Oncology Group, the Pacific Pediatric Neuro-Oncology Consortium (PNOC)and the Pediatric Brain Tumor Consortium (PBTC). Dr. Leary works with laboratory investigators at the Fred Hutchinson Cancer Research Center and the Seattle Children's Research Institute as well as the Pathology Department at Seattle Children's Hospital to identify novel therapeutic targets and tests. The goal of her clinical and translational research is to improve outcomes for brain tumor patients by developing biologically targeted therapeutics.
Victor received his M.D. from the University of Wisconsin-Madison and completed his residency in neurology and NINDS fellowship programs at Massachusetts General Hospital. Prior to residency, he was Staff Associate in the Experimental Therapeutics Branch at the NCI. A world-renowned expert in brain tumor research and treatment, he is currently Emeritus Professor of Neuro-Oncology at The UT M. D. Anderson Cancer Center and a past Chairman of the Department of Neuro-Oncology and Director of the Multidisciplinary Brain Tumor Center. He is also a Clinical Professor, Department of Neurosurgery, UCSF Medical School. Victor has authored more than 380 publications including the book, Cancer in the Nervous System, in his 50-year research career.
Prior to 1988, Victor was a professor at UCSF in the Departments of Neurosurgery and Pharmaceutical Chemistry and Chief of the Neuro-Oncology Service of the Brain Tumor Research Center. He is also the founder and first president (1995-97) of the Society for Neuro-Oncology.
Victor is widely respected for pharmacokinetics studies of anticancer drugs in the brain and cerebrospinal fluid, experimental and clinical studies of chemotherapy during radiation therapy, chemotherapy regimens for the treatment of gliomas, and studies of chemotherapy and radiation therapy for childhood medulloblastoma and ependymoma. He has developed combination chemotherapy and chemoradiation treatments that reflected translation from laboratory to clinic that were successful in clinical trials and investigation. He also directed the first National Cooperative Drug Discovery Group program to develop inhibitors of the protein tyrosine kinase domain of c-Src between 1983 and 2000. His most recent laboratory research efforts use reverse phase protein lysate microarrays to understand relative hypoxia and metabolic stress he coupled with new cell-based 2-dimensional and 3-dimensional assays in an effort to speed the development of new drug and drug combinations to selectively inhibit signal transduction pathways critical to tumor proliferation.
Michael began his career in Neuro-Oncology as a Fellow at the University of California San Francisco in 1985. Following a two year training program, he was recruited to the Faculty in 1988 and has remained at UCSF since that time, and is now Professor-in-Residence and the Charles B Wilson Chair of Neurosurgery. His career interests center around patient care, and clinical and translational research. He became the Project Leader of the North America Brain Tumor Consortium (NABTC) and led that group for 15 years. When the NABTC merged with the NABTT (and became the Adult Brain Tumor Consortium) he was named co-Project Leader until stepping down from this multi-institutional early phase clinical trials group in early 2014. In 2009, he was awarded the Project Leadership of what is called the Ivy Foundation Early Phase Clinical Trials Consortium, a group of now 7 major academic centers who conduct clinical and translation research in adults with brain cancer.
He was the Institutional site Principal Investigator for the Pediatric Brain Tumor Consortium (PBTC) for over 10 years, ending that role in 2012. At that time he formed the Pacific Pediatric Neuro-Oncology Consortium (PNOC), a multi-institutional consortium of now 11 major academic centers across the United States, conducing early phase, precision-focused, clinical trials in young children and adolescents.
Michael is Program Leader of the Neurological Oncology Program for the Helen Diller Comprehensive Cancer Center at UCSF, and for many years was the Director of Translational Research for the Neuro- Oncology program within the Departments Brain Tumor Research Center.
As noted above, his major interests are early phase clinical trials research, and the translational studies that precede and inform those trials in both adults and children. He has published over 300 articles since 1985 in Neuro-Oncology, and is part of the Editorial board of Neuro-Oncology, Journal of Neuro-Oncology and Journal of Clinical Oncology.
His greatest award has been the privilege to treat patients with malignant brain tumors, and to be associated with physicians and researchers in the field.
Jerald is a Member of the Clinical Research Division of the Fred Hutchinson Cancer Research Center, a Professor of Medicine, and an Adjunct Professor of Pathology at the University of Washington School of Medicine. He is the Director the Radich Lab and the Molecular Oncology Lab at the Fred Hutchinson Cancer Research Center. He serves as Chair of the Leukemia Translational Medicine Committee of the Southwest Oncology Group, co-chair of the NCI/NIH Leukemia Steering Committee, and is on the Board of Scientific Counselors, NIH Genome Research Institute. He is the Chair of the CML Committee of the National Comprehensive Cancer Network, a member of the EuroLeukemiaNet CML committees, and is on the Scientific Board of the International CML Foundation and the Max Foundation. His research interests include the molecular genetics of leukemia and the detection of minimal residual disease. The Radich Lab works in close collaboration with the clinical research performed at FHCRC, as well as collaborations with large clinical trials of the Southwest Oncology Group. Jerry earned his M.D. degree from the University of California Davis, School of Medicine.
Mike led the early concept and design efforts of EMulate Therapeutics' platform technology, known as Molecular Interrogation and Data Systems (MIDS), pioneering new concepts in signal acquisition, post signal processing, and signal transduction. His career in health care in both the private and public sectors, together with his background in electronics and RF design and engineering, has provided a valuable multidisciplinary framework for enabling and executing innovation within the Company.
Charles is The Gregory Foltz, MD Endowed Director of the Ben & Catherine Ivy Center for Advanced Brain Tumor Treatment at Swedish Neuroscience Specialists. Charles is a board-certified neurosurgeon who specializes in brain tumors with a combination of hands-on neurosurgery and high-level laboratory research. Prior to joining Swedish, Charles served as Associate Clinical Professor at UCSF Department of Neurological Surgery, Staff Neurosurgeon at California Pacific Medical Center and Scientist at California Pacific Medical Center Research Institute.
Xavier is the principal scientist for EMulate Therapeutics overseeing pre-clinical research and the application of EMulate Therapeutics technology in multiple disease areas. He has more than 20 years of experience in basic and neurological clinical research, including Alzheimer’s research, neuron biology, cancer research, bioengineering and biophysics.
He has advised emerging biotechnology companies, most notably Cytokinetics and ENG3. Xavier has also served on non-profit Scientific Advisory boards for such organizations as the Brain Health and Healing Foundation and published broadly in multiple areas of science and medicine.
Xavier received his doctoral degree in Neurobiology & Behavior from the University of Washington. His doctoral training was followed by two post-doctoral fellowships within the University of Washington’s Department of Bioengineering. He is currently an affiliate assistant professor in the School of Medicine at the University of Washington.
Gabriel, Distinguished Scientist, is the former Director of Molecular Biology for Dendreon Corporation, former Senior Scientist at Upjohn Company/Pharmacia-Upjohn and Senior Staff Fellow at the National Institutes of Health. Gabriel holds a PhD from the University of Zurich, and was a Postdoctoral Fellow at Yale University.